George Clooney, a leading Democratic fundraiser, has publicly called on Mr. Biden to drop out of the race and said his party would lose the election if he held out. He said Mr. Biden had won many challenges over the past four years, but one battle he could not win was against the years. It's heartbreaking to say, but the Biden I was with at the fundraiser three weeks ago is no longer the big man of 2010. He's not even the Biden of 2020. He's the guy we saw in the debate.